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. 2014 Dec;8(4):289-91.
doi: 10.1007/s12079-014-0255-5. Epub 2014 Nov 1.

Hormesis: from mainstream to therapy

Edward J Calabrese  1
Affiliations

Hormesis: from mainstream to therapy

Edward J Calabrese. J Cell Commun Signal. 2014 Dec.

Abstract

This issue of the Journal of Cell Communication and Cell Signaling on hormetic mechanisms represents an important step in the evolution of the hormesis dose response concept. Since its modern resurgence in the late 1970s the widespread occurrence of hormesis has been in search of its underlying mechanisms. The present integrative set of papers builds upon significant recent advances in the elucidation of hormetic mechanisms and provides the reader with a deep and extensive view of the concept of hormesis from a broad range of researcher perspectives and in many biomedical applications.

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Figures

Fig. 1
Fig. 1
Dose-response curve depicting the quantitative features of hormesis and its application to the concept of enhanced biological performance
See this image and copyright information in PMC

References

    1. Calabrese EJ. Historical blunders: how toxicology got the dose-response relationship half right. Cell Mol Biol. 2005;51(7):643–654. - PubMed
    1. Calabrese EJ. Hormesis: why it is important to toxicology and toxicologists. Environ Toxicol Chem. 2008;27(7):1451–1474. doi: 10.1897/07-541.1. - DOI - PubMed
    1. Calabrese EJ. Hormesis mechanisms. Crit Rev Toxicol. 2013;43(7):580–606. doi: 10.3109/10408444.2013.808172. - DOI - PubMed
    1. Calabrese EJ, Baldwin LA. Chemical hormesis: its historical foundations as a biological hypothesis. Hum Exp Toxicol. 2000;19(1):2–31. doi: 10.1191/096032700678815585. - DOI - PubMed
    1. Calabrese EJ, Baldwin LA. The marginalization of hormesis. Hum Exp Toxicol. 2000;19(1):32–40. doi: 10.1191/096032700678815594. - DOI - PubMed