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. 2014 Nov 21;16(22):5914-7.
doi: 10.1021/ol502921a. Epub 2014 Nov 4.

Copper-mediated α-trifluoromethylation of N-phenylcinnamamides coupled with dearomatization: access to trifluoromethylated 1-azaspiro[4.5]decanes

Guifang Han  1 , Qiang Wang, Yuxiu Liu, Qingmin Wang
Affiliations

Copper-mediated α-trifluoromethylation of N-phenylcinnamamides coupled with dearomatization: access to trifluoromethylated 1-azaspiro[4.5]decanes

Guifang Han et al. Org Lett. .

Abstract

Copper-mediated intramolecular trifluoromethylation of N-phenylcinnamamides coupled with cyclization and dearomatization was used to construct various trifluoromethylated 1-azaspiro[4.5]decanes in moderate to high yields and with excellent regioselectivity and diastereoselectivity.

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