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Randomized Controlled Trial
. 2014 Dec 10;32(35):3974-81.
doi: 10.1200/JCO.2014.57.3493. Epub 2014 Nov 3.

Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial

Melissa M Hudson  1 , Wendy Leisenring  2 , Kayla K Stratton  2 , Nina Tinner  2 , Brenda D Steen  2 , Susan Ogg  2 , Linda Barnes  2 , Kevin C Oeffinger  2 , Leslie L Robison  2 , Cheryl L Cox  2
Affiliations
Randomized Controlled Trial

Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial

Melissa M Hudson et al. J Clin Oncol. .

Abstract

Purpose: To determine whether the addition of advanced-practice nurse (APN) telephone counseling to a printed survivorship care plan (SCP) significantly increases the proportion of at-risk survivors who complete cardiomyopathy screening.

Patients and methods: Survivors age ≥ 25 years participating in the Childhood Cancer Survivor Study who received cardiotoxic therapy and reported no history of cardiomyopathy screening in the previous 5 years were eligible for enrollment. The 472 participants (mean age, 40.1 years; range, 25.0 to 59.0; 53.3% women) were randomly assigned to either standard care, consisting of an SCP summarizing cancer treatment and cardiac health screening recommendations (n = 234), or standard care plus two APN telephone counseling sessions (n = 238). The primary outcome-completion of cardiomyopathy screening within 1 year-was validated by medical records and compared between the two arms using adjusted relative risks (RRs) with 95% CIs.

Results: Participants in the standard and APN counseling groups were not statistically different by demographic or clinical characteristics. At the time of 1-year follow-up, 107 (52.2%) of 205 survivors in the APN group completed screening compared with 46 (22.3%) of 206 survivors in the non-APN group (P < .001). With adjustment for sex, age (< 30 v ≥ 30 years), and Children's Oncology Group-recommended screening frequency group (annual, 2 years, or 5 years), survivors in the APN group were > 2× more likely than those in the control group to complete the recommended cardiomyopathy screening (RR, 2.31; 95% CI, 1.74 to 3.07).

Conclusion: The addition of telephone counseling to an SCP with cardiac health screening recommendations increases cardiomyopathy screening in at-risk survivors.

Trial registration: ClinicalTrials.gov NCT01003574.

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Conflict of interest statement

Authors' disclosures of potential conflicts of interest are found in the article online at www.jco.org. Author contributions are found at the end of this article.

Figures

Fig 1.
Fig 1.
Evaluation of Cardiovascular Health Outcomes Among Survivors study design. APN, advanced-practice nurse; SCP, survivorship care plan.
Fig 2.
Fig 2.
CONSORT diagram showing participant distribution in the Evaluation of Cardiovascular Health Outcomes Among Survivors study. APN, advanced-practice nurse; SCP, survivorship care plan.
See this image and copyright information in PMC

Comment in

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