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Comment
. 2014 Oct 16;41(4):505-6.
doi: 10.1016/j.immuni.2014.09.020.

Thinking inside the box: endogenous α-anomeric lipid antigens

Jessica Kim  1 , Ji Hyung Kim  1 , Florian Winau  2
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Comment

Thinking inside the box: endogenous α-anomeric lipid antigens

Jessica Kim et al. Immunity. .
Free article

Abstract

The most powerful iNKT cell antigen is α-galactosylceramide (α-GalCer), derived from the marine sponge. However, α-anomeric glycolipids are thought to be absent in mammals. In this issue of Immunity, Kain et al., (2014) demonstrate the presence of mammalian α-linked glycosylceramides, such as α-GalCer.

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