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Comment
. 2014 Oct 16;41(4):509-11.
doi: 10.1016/j.immuni.2014.10.003.

MicroRNAs in Tfh cells: micromanaging inflammaging

Di Yu  1
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MicroRNAs in Tfh cells: micromanaging inflammaging

Di Yu. Immunity. .
Free article

Abstract

MicroRNA (miR)-146a-deficient mice develop low-grade, chronic, and systemic inflammation, similar to inflammaging. Hu et al. (2014) demonstrate that the lack of miR-155 prevents the accumulation of Tfh cells and inflammaging in miR-146a-deficient mice. They identify Fosl2 as a functionally important target of miR-155 in Tfh cells.

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