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Comment
. 2014 Nov;4(11):OF13.
doi: 10.1158/2159-8290.CD-RW2014-186. Epub 2014 Sep 4.

BCR-ABL1 compound mutations drive ponatinib resistance

No authors listed
Comment

BCR-ABL1 compound mutations drive ponatinib resistance

No authors listed. Cancer Discov. 2014 Nov.

Abstract

BCR-ABL1 compound mutations harboring T315I are resistant to multiple TKIs, including ponatinib.

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Comment on

  • BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Ph chromosome-positive leukemia.
    Zabriskie MS, Eide CA, Tantravahi SK, Vellore NA, Estrada J, Nicolini FE, Khoury HJ, Larson RA, Konopleva M, Cortes JE, Kantarjian H, Jabbour EJ, Kornblau SM, Lipton JH, Rea D, Stenke L, Barbany G, Lange T, Hernández-Boluda JC, Ossenkoppele GJ, Press RD, Chuah C, Goldberg SL, Wetzler M, Mahon FX, Etienne G, Baccarani M, Soverini S, Rosti G, Rousselot P, Friedman R, Deininger M, Reynolds KR, Heaton WL, Eiring AM, Pomicter AD, Khorashad JS, Kelley TW, Baron R, Druker BJ, Deininger MW, O'Hare T. Zabriskie MS, et al. Cancer Cell. 2014 Sep 8;26(3):428-442. doi: 10.1016/j.ccr.2014.07.006. Epub 2014 Aug 14. Cancer Cell. 2014. PMID: 25132497 Free PMC article.

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