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Comment
. 2014 Nov 11;111(45):15869-70.
doi: 10.1073/pnas.1418570111. Epub 2014 Nov 3.

Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics

Nimish D Kathale  1 , Andrew C Liu  2
Affiliations
Comment

Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics

Nimish D Kathale et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
A holistic view of the human biological clock, illustrating the peak times of selected biological variables, including genes (in black), physiology (best times appear in blue), pathology and disease (worst times are red), and treatment (chronotherapy show in green). The yin–yang symbol represents dynamic interactions of seemingly contrary forces in a coherent system. The sleep/wake cycle is the most obvious manifestation of circadian rhythms. The core clock genes are Bmal1, Clock, Cry1, Per1, and Per2. Hmgcr and Abcb1a2 are two circadian gene examples. ASPD, advanced sleep phase disorder; DSPD, delayed sleep phase disorder.
See this image and copyright information in PMC

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