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Comment
. 2014 Nov 11;111(45):15867-8.
doi: 10.1073/pnas.1418496111. Epub 2014 Nov 3.

Impact of early-stage HIV transmission on treatment as prevention

Kimberly A Powers  1 , Mirjam E Kretzschmar  2 , William C Miller  3 , Myron S Cohen  4
Affiliations
Comment

Impact of early-stage HIV transmission on treatment as prevention

Kimberly A Powers et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Initial growth, generation time, and R0. Red circles represent new cases. The horizontal distance between one case and those directly connected to it represents generation time Tg. The number of arrows emanating from a case represents the basic reproductive number R0. Increases from one new case at time 0 to 16 new cases at time t is compatible with, for example, (A) two discrete generations after infection introduction, each with a longer time Tg between generations and R0 = 4; or (B) four discrete generations, each with a shorter Tg and R0 = 2. (In reality, generations will be distributed in time, but we present discrete generations to illustrate basic concepts.)
Fig. 2.
Fig. 2.
Preintervention delay and intervention impact. Curves show the distribution of times within the infectious period that onward transmissions occur for two hypothetical scenarios that differ in terms of the early-stage transmission contribution. Red and green regions represent transmissions unaverted and averted by the intervention, respectively. The area under the curve represents R0. (A) Smaller proportion of early-stage transmissions (higher R0). (B) Higher proportion of early-stage transmissions (lower R0). In both scenarios, earlier intervention initiation (smaller T) will result in greater fractions of averted infections, but the prevention impact will be greater in A than in B as long as early transmission is missed.
See this image and copyright information in PMC

Comment on

References

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