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. 1989 Mar;63(3):1465-9.
doi: 10.1128/JVI.63.3.1465-1469.1989.

Identification of a transforming gene of human papillomavirus type 16

A Tanaka  1 , T Noda, H Yajima, M Hatanaka, Y Ito
Affiliations

Identification of a transforming gene of human papillomavirus type 16

A Tanaka et al. J Virol. 1989 Mar.

Abstract

Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating activity. Analysis of these cDNA clones indicated that the E7 open reading frame alone is responsible for inducing both steps of this cell transformation.

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