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. 2014 Oct;29(10):1411-5.
doi: 10.3346/jkms.2014.29.10.1411. Epub 2014 Oct 8.

Rebleeding after initial endoscopic hemostasis in peptic ulcer disease

Mi Jin Hong  1 , Sun-Young Lee  1 , Jeong Hwan Kim  1 , In-Kyung Sung  1 , Hyung Seok Park  1 , Chan Sup Shim  1 , Choon Jo Jin  1
Affiliations

Rebleeding after initial endoscopic hemostasis in peptic ulcer disease

Mi Jin Hong et al. J Korean Med Sci. 2014 Oct.

Abstract

Endoscopic hemostasis is the first-line treatment for upper gastrointestinal bleeding (UGIB). Although several factors are known to be risk factors for rebleeding, little is known about the use of antithrombotics. We tried to verify whether the use of antithrombotics affects rebleeding rate after a successful endoscopic hemostasis for peptic ulcer disease (PUD). UGIB patients who underwent successful endoscopic hemostasis were included. Rebleeding was diagnosed when the previously treated lesion bled again within 30 days of the initial episode. Of 522 UGIB patients with PUD, rebleeding occurred in 93 patients (17.8%). The rate of rebleeding was higher with aspirin medication (P=0.006) and after a long endoscopic hemostasis (P<0.001). Of all significant variables, procedure time longer than 13.5 min was related to the rate of rebleeding (OR, 2.899; 95% CI, 1.768-4.754; P<0.001) on the logistic regression analysis. The rate of rebleeding after endoscopic hemostasis for PUD is higher in the patients after a long endoscopic hemostasis. Endoscopic hemostasis longer than 13.5 min is related to rebleeding after a successful endoscopic hemostasis for PUD.

Keywords: Endoscopic; Hemostasis; Peptic Ulcer; Rebleeding; Upper Gastrointestinal Bleeding.

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Conflict of interest statement

The authors declare that there is nothing to disclose except the acknowledgment that the study was supported by the National Research Foundation of Korea.

References

    1. Seo YS, Kim YH, Ahn SH, Yu SK, Baik SK, Choi SK, Heo J, Hahn T, Yoo TW, Cho SH, et al. Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis. J Korean Med Sci. 2008;23:635–643. - PMC - PubMed
    1. Chiu PW, Joeng HK, Choi CL, Kwong KH, Ng EK, Lam SH. Predictors of peptic ulcer rebleeding after scheduled second endoscopy: clinical or endoscopic factors? Endoscopy. 2006;38:726–729. - PubMed
    1. Travis AC, Wasan SK, Saltzman JR. Model to predict rebleeding following endoscopic therapy for non-variceal upper gastrointestinal hemorrhage. J Gastroenterol Hepatol. 2008;23:1505–1510. - PubMed
    1. Suk KT, Kim HS, Lee CS, Lee IY, Kim MY, Kim JW, Baik SK, Kwon SO, Lee DK, Ham YL. Clinical outcomes and risk factors of rebleeding following endoscopic therapy for nonvariceal upper gastrointestinal hemorrhage. Clin Endosc. 2011;44:93–100. - PMC - PubMed
    1. Suehiro T, Yakeishi Y, Sakai F, Matsuzaki K, Sanefuji K, Toyokawa T, Shioshita K, Sugie Y, Okudaira Y, Kano T, et al. Gastrointestinal bleeding associated with antithrombotic therapy in the elderly in Japan. Hepatogastroenterology. 2012;59:774–777. - PubMed

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