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Case Reports
. 2014 Nov;34(6):463-5.
doi: 10.3343/alm.2014.34.6.463. Epub 2014 Oct 28.

A case of salivary-type amylase-producing multiple myeloma presenting as mediastinal plasmacytoma and myelomatous pleural effusion

Soon Jung Ok  1 , In-Suk Kim  2 , Eun Yup Lee  1 , Jeong-Eun Kang  3 , Sun-Min Lee  2 , Moo-Kon Song  4
Affiliations
Case Reports

A case of salivary-type amylase-producing multiple myeloma presenting as mediastinal plasmacytoma and myelomatous pleural effusion

Soon Jung Ok et al. Ann Lab Med. 2014 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1
Histologic examination of the pleural fluid (A), mediastinal mass (B and C), and bone marrow (D, E, and F). (A) Cytospin analysis of pleural fluid shows increased plasma cells with eccentric nuclei and abundant basophilic cytoplasm, consistent with myelomatous pleural effusion (Wright-Giemsa stain, ×200). (B) The histologic examination of mediastinal plasmacytoma reveals diffuse infiltration of mature plasma cells (hematoxylin and eosin stain, ×200). (C) Immunohistochemical staining of mediastinal plasmacytoma shows CD138 positivity (×1,000). (D) Bone marrow aspiration shows moderate proliferation of neoplastic plasma cells, consistent with plasma cell myeloma (Wright-Giemsa stain, ×1,000). (E and F) Immunohistochemical staining of bone marrow shows monoclonal proliferation of lambda-restricted plasma cells (kappa [E] and lambda [F] stains, ×200).
Fig. 2
Fig. 2
Amylase isoenzyme electrophoreses of serum and urine shows that the level of the salivary-type isoenzyme is the highest, consistent with salivary-type amylase-producing myeloma. Abbreviations: S1, salivary-type isoenzyme 1; S2, salivary-type isoenzyme 2; S3, salivary-type isoenzyme 3; P1, pancreatic-type isoenzyme 1.
See this image and copyright information in PMC

References

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