Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct;40(5):220-4.
doi: 10.5125/jkaoms.2014.40.5.220. Epub 2014 Oct 24.

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Siamak Yaghobee  1 , Afshin Khorsand  2 , Amir Alireza Rasouli Ghohroudi  2 , Khashayar Sanjari  3 , Mahdi Kadkhodazadeh  4
Affiliations

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

Siamak Yaghobee et al. J Korean Assoc Oral Maxillofac Surg. 2014 Oct.

Abstract

Objectives: This study aimed to assess and compare the levels of interleukin-1beta (IL-1β) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth.

Materials and methods: This study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-implantitis next to healthy teeth. The crevicular fluid was collected using absorbent cones and transferred to the laboratory. Specimens were evaluated by ELISA for interleukin levels. Data were analyzed using repeated measures ANOVA and Bonferroni tests (P<0.05).

Results: Levels of IL-1β in the crevicular fluid around implants with peri-implantitis were significantly higher than around healthy implants (P=0.002); the latter was significantly higher than around healthy teeth (P=0.015). A significant difference was found in the level of IL-6 in the crevicular fluid around implants with peri-implantitis and healthy implants (P=0.049) and also between implants with peri-implantitis and healthy teeth (P<0.001).

Conclusion: Within the limitations of this study, significant differences exist in the levels of IL-1β and IL-6 in the crevicular fluid of implants with peri-implantitis, healthy implants, and healthy teeth. More studies with larger sample sizes in different populations are necessary.

Keywords: Dental implants; Gingival crevicular fluid; Interleukin-1beta; Interleukin-6; Peri-implantitis.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

References

    1. Abrishami MR, Sabour S, Nasiri M, Amid R, Kadkhodazadeh M. Comparison of the reproducibility of results of a new peri-implantitis assessment system (implant success index) with the Misch classification. J Korean Assoc Oral Maxillofac Surg. 2014;40:61–67. - PMC - PubMed
    1. Roos-Jansåker AM, Lindahl C, Renvert H, Renvert S. Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol. 2006;33:290–295. - PubMed
    1. Ata-Ali J, Flichy-Fernandez AJ, Ata-Ali F, Penarrocha-Diago M, Penarrocha-Diago M. Clinical, microbiologic, and host response characteristics in patients with peri-implant mucositis. Int J Oral Maxillofac Implants. 2013;28:883–890. - PubMed
    1. Petković AB, Matić SM, Stamatović NV, Vojvodić DV, Todorović TM, Lazić ZR, et al. Proinflammatory cytokines (IL-1beta and TNF-alpha) and chemokines (IL-8 and MIP-1alpha) as markers of peri-implant tissue condition. Int J Oral Maxillofac Surg. 2010;39:478–485. - PubMed
    1. Sanz M, Chapple IL Working Group 4 of the VIII European Workshop on Periodontology. Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol. 2012;39(Suppl 12):202–206. - PubMed