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. 1989 Feb 9;337(6207):525-31.
doi: 10.1038/337525a0.

Designing CD4 immunoadhesins for AIDS therapy

D J Capon  1 , S M Chamow, J Mordenti, S A Marsters, T Gregory, H Mitsuya, R A Byrn, C Lucas, F M Wurm, J E Groopman, et al.
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Designing CD4 immunoadhesins for AIDS therapy

D J Capon et al. Nature. .

Abstract

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

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