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Review
. 2015 Jan;13(1):6-17.
doi: 10.2450/2014.0063-14. Epub 2014 Sep 12.

Hepatitis E: an old infection with new implications

Giuseppe Marano  1 , Stefania Vaglio  2 , Simonetta Pupella  1 , Giuseppina Facco  3 , Maria Bianchi  4 , Gabriele Calizzani  1 , Fabio Candura  1 , Liviana Catalano  1 , Blandina Farina  1 , Monica Lanzoni  5 , Vanessa Piccinini  1 , Giancarlo M Liumbruno  1 , Giuliano Grazzini  1
Affiliations
Review

Hepatitis E: an old infection with new implications

Giuseppe Marano et al. Blood Transfus. 2015 Jan.
No abstract available

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Figures

Figure 1
Figure 1
A schematic representation of the genomic organisation of the hepatitis E virus (HEV). ORF: open reading frame; MT: methyltransferase; Y: Y domain; PCP: a papain-like cysteine protease; Hel: helicase; HVR: hypervariable region; X: macro-domain; RdRp: RNA-dependent RNA polymerase; JR: junction region; SL: stem-loop structure; NCR: non-coding region. Modified from Cao D et al., 2010.
Figure 2
Figure 2
Worldwide distribution of hepatitis E virus infection per genotype (Gt). Modified from Kamar N et al., 2012.
Figure 3
Figure 3
Schematic representation of the course of acute HEV infection. HEV RNA becomes detectable in stools and serum during the incubation period, with the subsequent appearance of IgM and IgG HEV antibodies. The level of IgM antibodies peaks early and then these antibodies become undetectable during recovery, whereas the level of IgG antibodies keeps on increasing and can persist in the long term. Clinical symptoms (fatigue, nausea, and jaundice) begin shortly after the increase of serum alanine aminotransferase (ALT) levels. HEV RNA disappears from the serum with recovery, whereas the virus usually remains detectable longer in stools (arrows). Modified from Hoofnagle JH, 2012.
See this image and copyright information in PMC

References

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