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Case Reports
. 2014 Oct;6(4):359-62.
doi: 10.4103/0974-7796.141006.

Urinary bladder metastasis from lung adenocarcinoma: A rare cause of hematuria

Kan Wai Man Raymond  1 , Ting Shun Hin  2 , Kan Chi Fai  1 , Chan Wai Hee Steve  1
Affiliations
Case Reports

Urinary bladder metastasis from lung adenocarcinoma: A rare cause of hematuria

Kan Wai Man Raymond et al. Urol Ann. 2014 Oct.

Abstract

We presented an unusual case of hematuria caused by a solitary bladder metastasis from lung adenocarcinoma. A confident diagnosis of secondary adenocarcinoma of the bladder was made by clinical suspicion based on patient's past history, careful examination of tumor morphology, and a directed panel (cytokeratin [CK] 7/CK20/thyroid transcription factor 1) of immunohistochemistry. We sought, through sharing our experience in the investigative and diagnostic process, to contribute to the better understanding of this unusual cause of hematuria.

Keywords: Adenocarcinoma; bladder metastasis; hematuria.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Figure 1
Figure 1
Suspicious urine cytology: Papanicolaou stain, ×600
Figure 2
Figure 2
Computed tomography urogram. Left: Contrast phase. Right: Urogram phase
Figure 3
Figure 3
Left: Sessile vascular tumor. Right: Distorted and elevated surrounding mucosa
Figure 4
Figure 4
Brain metastasis. Left: Features diagnostic of adenocarcinoma. Right: Thyroid transcription factor 1 positivity
Figure 5
Figure 5
Bladder tumor. Left: Mucosal involvement by tumor with an intact overlying transitional cell epithelium (arrows). Right: Detrusor muscle infiltration
Figure 6
Figure 6
Immunohistochemistry of bladder tumor. Top left: Routine H and E stain. Top right: Cytokeratin 7 (CK7) +ve. Bottom right: CK20 – ve. Bottom left: Thyroid transcription factor 1 +ve
See this image and copyright information in PMC

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