Serum ferritin levels and the development of metabolic syndrome and its components: a 6.5-year follow-up study

Abstract

Background: The aim of this study was to investigate the relationship between changes in serum ferritin concentrations and the development of metabolic syndrome (MetS) and its components over a 6.5 year follow-up period in Finnish adults.

Methods: Adults born in Pieksämäki, Finland, in 1942, 1947, 1952, 1957, and 1962 (n = 1294) were invited to health checkups between 1997 and 1998 and 2003 and 2004. All of the required variables for both checkups were available from 691 (53%) subjects (289 men and 402 women). MetS was defined by the National Cholesterol Education Program criteria.

Results: During the 6.5-year follow-up period, 122 (18%) subjects developed incident cases of MetS. Increases in serum ferritin levels were significantly higher in both women and men with incident MetS compared with women and men without MetS (p = 0.04, p = 0.03). Also, serum ferritin levels increased significantly less in women in whom the criteria for MetS resolved during the follow-up period (p = 0.01). Increases in serum ferritin levels were significantly lower in women in whom the glucose criterion for MetS resolved, and higher in women for whom the waist criterion developed (p = 0.01 and p <0.001, respectively). Serum ferritin levels decreased significantly more in men in whom the triglyceride criterion for MetS resolved during the follow-up period (p = 0.01). There was a clear and significant correlation between change in serum ferritin level and change in waist circumference both in men and women (p <0.001, p <0.01). In addition, correlations between change in serum ferritin level and change in plasma triglyceride as well as glucose levels were strongly positive in men (p <0.001). There was negative correlation between change in serum ferritin and plasma high density cholesterol level both in men and women.

Conclusions: Increases in serum ferritin over a 6,5 year period are associated with development of MetS in both men and women. Whereas, lower increases in serum ferritin over the same timeframe are associated with resolution of hypertriglyceridemia in men and hyperglycemia in women. Increases in waist circumference was positively correlated with increases in serum ferritin in both men and women.

Keywords: Ferritin; Metabolic syndrome; Obesity.

Figure 1

Legends: All results are adjusted for age, baseline smoking, baseline physical activity, baseline use of alcohol, baseline serum ferritin level, baseline body mass index and baseline hs-CRP. Waist criterion = Waist >102 cm (male) or >88 cm (female), Glucose criterion = FP-glucose ≥5.6 mmol/L, Trigly criterion = Triglycerides >1.7 mmol/l or medication for dyslipidemia, HDL criterion = HDL–cholesterol <1.03 mmol/l (men) or <1.29 mmol/l (women) or medication for dyslipidemia, BP criterion = Systolic blood pressure ≥130 mmHg or diastolic ≥85 mmHg or antihypertensive medication.