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Review
. 2014 Oct;65(3):167-75.
doi: 10.5114/pjp.2014.45779.

Significance of selected antioxidant enzymes in cancer cell progression

Rafał Jakub Bułdak  1 , Łukasz Bułdak, Michał Kukla, Andrzej Gabriel, Krystyna Zwirska-Korczala
Affiliations
Free article
Review

Significance of selected antioxidant enzymes in cancer cell progression

Rafał Jakub Bułdak et al. Pol J Pathol. 2014 Oct.
Free article

Abstract

Antioxidant enzymes (AOEs), including superoxide dismutase isoenzymes (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) along with glutathione reductase (GR), reduced glutathione (GSH) and glutathione transferase (GST), are thought to be necessary for life process in all oxygen-metabolizing cells by removing reactive oxygen species (ROS). The biological significance of AOEs in transformed cells is still unclear, but their capacity to survive may be affected by changes in cellular process such as proliferation, invasiveness, migration, apoptosis and drug resistance. This review summaries the significance of antioxidant enzymes in cancer cell progression mainly in an in vitro context.

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