Comment
doi: 10.1016/j.devcel.2014.10.008.
Multigenerational chromatin marks: no enzymes need apply
Affiliations
- PMID: 25373774
- DOI: 10.1016/j.devcel.2014.10.008
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Comment
Multigenerational chromatin marks: no enzymes need apply
Dev Cell.
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Abstract
Epigenetic memory stably maintains and transmits information during genome replication. Recently in Science, Gaydos et al. (2014) show that repressive chromatin marks exhibit transgenerational stability in the absence of chromatin-modifying enzymes in Caenorhabditis elegans, in contrast to work in flies suggesting that such proteins mediate stable inheritance of epigenetic modifications.
Comment on
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Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells.Cell Rep. 2012 Nov 29;2(5):1169-77. doi: 10.1016/j.celrep.2012.09.019. Epub 2012 Oct 25. Cell Rep. 2012. PMID: 23103171 Free PMC article.
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Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.Science. 2014 Sep 19;345(6203):1515-8. doi: 10.1126/science.1255023. Epub 2014 Sep 18. Science. 2014. PMID: 25237104 Free PMC article.