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. 2012 Jun;72(6):507-512.
doi: 10.1055/s-0032-1314959.

Importance of HPV Genotyping for the Screening, Therapy and Management of Cervical Neoplasias

M Jentschke  1 , P Soergel  1 , P Hillemanns  1
Affiliations

Importance of HPV Genotyping for the Screening, Therapy and Management of Cervical Neoplasias

M Jentschke et al. Geburtshilfe Frauenheilkd. 2012 Jun.

Abstract
in English, German

In the last decade, the detection of human papillomaviruses (HPV) has become increasingly important in cervical cancer screening and the treatment of cancer precursors. HPV screening is recommended for the further evaluation of abnormal Pap tests or during follow-up after treating precancerous lesions. Several randomised controlled studies have shown that screening for cervical cancer using HPV detection can be more effective than cytology alone. Genotyping of different high-risk HPV (hrHPV) types obtained from smear tests has not yet gained widespread acceptance in clinical practice. However, significant differences have been noted in the oncogenicity of hrHPV genotypes. HPV 16 is by far the most common and oncogenic genotype. Genotyping of hrHPV could be helpful for the risk stratification of HPV-positive women.

Der Nachweis humaner Papillomviren (HPV) im Rahmen der Vorsorge und Behandlung des Zervixkarzinoms und insbesondere seiner Vorstufen hat in den vergangenen Jahren zunehmend an Bedeutung gewonnen. Die HPV-Bestimmung wird beispielsweise zur weiteren Abklärung auffälliger Pap-Abstriche oder in der Nachsorge nach Behandlung präinvasiver Veränderungen empfohlen. Mehrere randomisierte kontrollierte Studien konnten zudem eine Überlegenheit gegenüber einem reinen Zytologie-Screening zeigen. Die Typisierung der unterschiedlichen Hochrisiko-HPV-Typen aus Abstrichproben hat dagegen erst in geringerem Maße Anwendung in der Praxis gefunden. Es zeigen sich jedoch große Unterschiede in der onkogenen Potenz und Relevanz der unterschiedlichen Genotypen. HPV 16 hat zahlenmäßig und auch prospektiv mit Abstand die höchste Bedeutung für die Entstehung zervikaler Neoplasien. Die Genotypisierung kann daher für eine bessere Risikostratifizierung HPV-positiver Frauen hilfreich sein.

Keywords: cervical cancer; cervical interepithelial neoplasia (CIN); human papillomavirus.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest M. Jentschke received a speakerʼs fee and travel costs from Abbott GmbH & Co. KG, Wiesbaden.

Figures

Fig. 1
Fig. 1
Squamous cell carcinoma of the uterine cervix pT1b1, N0, G2 after radical endoscopic hysterectomy and combined blue dye/technetium 99m radiocolloid (intracervical) identification of sentinel lymph nodes.
Fig. 2
Fig. 2
Colposcopy of a CIN 2 lesion after application of 5 % acetic acid. Insert shows diagnostic fluorescence imagíng of the same CIN 2 after the application of hexaminolevulinate.
See this image and copyright information in PMC

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