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. 2014;6(3):145-9.

Cumulative live birth rate and assisted reproduction: impact of female age and transfer day

M I Abuzeid  1 , O Bolonduro  2 , J La Chance  3 , T Abozaid  4 , M Urich  4 , K Ullah  4 , T Ali  4 , M Ashraf  1 , I Khan  4
Affiliations

Cumulative live birth rate and assisted reproduction: impact of female age and transfer day

M I Abuzeid et al. Facts Views Vis Obgyn. 2014.

Abstract

Background: Many studies on assisted reproductive technology examine live birth rate per cycle. However, after a cycle fails, couples often want to know what their chances are of having a live birth if they continue treatment. From a patients' perspective, the cumulative probability of live birth is more informative.

Materials and methods: This study includes patients who underwent fresh, frozen and non-donor ICSI cycles at our IVF unit between 2006-2012. Patients were divided into two groups; Group 1 represented those who underwent only Day 5 transfers, Group 2 represented only Day 3 transfers. Patients who underwent both were excluded. -Cycles were analyzed until the first live birth or the end of the 3rd cycle. Using Kaplan-Meier analysis, we estimated the cumulative live birth rates for each group and according to female age.

Results: The mean age for Group 1 was significantly lower than for Group 2. After 3 cycles, Group 1's CLBR was 79% versus 66% in Group 2. When analyzing the live births by age and group, there was a significant difference in the CLBR after 3 cycles with the women less than 35 years having the highest CLBR and the women 40 years or older having the lowest CLBR.

Conclusion: In women less than 35 years, excellent CLBR can be achieved irrespective of the transfer day. For women 40 years and above, better results of CLBR are observed with Day 5 transfers. Our findings may impact the counseling of couples considering IVF treatment.

Keywords: ART; ICSI; IVF; cumulative live birth rate; female age; transfer day.

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Figures

Fig. 1
Fig. 1. Overall CLBR for cycles 1, 2 and 3 by day of transfer (P < 0.001).
Fig. 2
Fig. 2. CLBR for women < 35 years by day of transfer (P > 0.05.
Fig. 3
Fig. 3. CLBR for women age 35-39 years by day of transfer (P < 0.05).
Fig. 4
Fig. 4. CLBR for women 40 years or older by day of transfer (P < 0.001).
See this image and copyright information in PMC

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