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. 2014:2014:697359.
doi: 10.1155/2014/697359. Epub 2014 Sep 3.

The possible efficacy of artichoke in fluconazole related hepatotoxicity

Hüseyin Kurt  1 , Omer Toprak  1 , Erdoğan Bülbül  2
Affiliations

The possible efficacy of artichoke in fluconazole related hepatotoxicity

Hüseyin Kurt et al. Case Reports Hepatol. 2014.

Abstract

Although fluconazole related hepatotoxicity (FRH) is rare, mortal acute hepatic necrosis and jaundice were reported in immunocompromised states such as acquired immunodeficiency syndrome (AIDS) and bone marrow transplant (BMT). We present a case of a patient with multiple sclerosis who developed hepatotoxicity with the use of a single 150 mg fluconazole tablet for fungal vaginitis, 10 days after methylprednisolone pulse treatment. Our patient's alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were decreased, 1200 U/L and 800 U/L, respectively, and bilirubin levels were consistent at 37 mg/dL. Artichoke which has anticholestatic and antioxidant properties was used by our patient. She consumed a 30 mg artichoke leaf extract tea 3 times a day. The bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months.

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Figures

Figure 1
Figure 1
Abdominal ultrasonography (coarsening in liver parenchyma and minimally prominent intrahepatic bile ducts).
Figure 2
Figure 2
Changings of ALT and AST levels.
Figure 3
Figure 3
Changings of bilirubin levels.
See this image and copyright information in PMC

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