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. 2014:2014:697359.
doi: 10.1155/2014/697359. Epub 2014 Sep 3.

The possible efficacy of artichoke in fluconazole related hepatotoxicity

Affiliations

The possible efficacy of artichoke in fluconazole related hepatotoxicity

Hüseyin Kurt et al. Case Reports Hepatol. 2014.

Abstract

Although fluconazole related hepatotoxicity (FRH) is rare, mortal acute hepatic necrosis and jaundice were reported in immunocompromised states such as acquired immunodeficiency syndrome (AIDS) and bone marrow transplant (BMT). We present a case of a patient with multiple sclerosis who developed hepatotoxicity with the use of a single 150 mg fluconazole tablet for fungal vaginitis, 10 days after methylprednisolone pulse treatment. Our patient's alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were decreased, 1200 U/L and 800 U/L, respectively, and bilirubin levels were consistent at 37 mg/dL. Artichoke which has anticholestatic and antioxidant properties was used by our patient. She consumed a 30 mg artichoke leaf extract tea 3 times a day. The bilirubin levels significantly declined at the end of the first week and all liver function tests were normalized within 2 months.

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Figures

Figure 1
Figure 1
Abdominal ultrasonography (coarsening in liver parenchyma and minimally prominent intrahepatic bile ducts).
Figure 2
Figure 2
Changings of ALT and AST levels.
Figure 3
Figure 3
Changings of bilirubin levels.

References

    1. Jacobson MA, Hanks DK, Ferrell LD. Fatal acute hepatic necrosis due to fluconazole. The American Journal of Medicine. 1994;96(2):188–190. - PubMed
    1. Mehmetçik G, Özdemirler G, Koçak-Toker N, Çevikbaş U, Uysal M. Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. Experimental and Toxicologic Pathology. 2008;60(6):475–480. - PubMed
    1. García Rodrǐguez LA, Duque A, Castellsague J, Pérez-Gutthann S, Stricker BHC. A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs. The British Journal of Clinical Pharmacology. 1999;48(6):847–852. - PMC - PubMed
    1. Wang J-L, Chang C-H, Young-Xu Y, Chan KA. Systematic review and meta-analysis of the tolerability and hepatotoxicity of antifungals in empirical and definitive therapy for invasive fungal infection. Antimicrobial Agents and Chemotherapy. 2010;54(6):2409–2419. - PMC - PubMed
    1. Björnsson E, Davidsdottir L. The long-term follow-up after idiosyncratic drug-induced liver injury with jaundice. Journal of Hepatology. 2009;50(3):511–517. - PubMed

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