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Review
. 2014 Oct 2;2(3):209-18.
eCollection 2014.

Prostate epithelial stem and progenitor cells

Oh-Joon Kwon  1 , Li Xin  2
Affiliations
Review

Prostate epithelial stem and progenitor cells

Oh-Joon Kwon et al. Am J Clin Exp Urol. .

Abstract

The classic androgen ablation and replacement experiment demonstrates that prostate epithelia possess extensive regenerative capacities and implies the existence of the prostate stem/progenitor cells. These cells may serve as the cells of origin for prostate cancer and their intrinsic property may dictate the clinical behaviors of the resulting diseases. Therefore, detailed characterization of these cells will potentially benefit disease prevention, diagnosis and prognosis. In this review, we describe several major in vitro and in vivo approaches that have been employed in the studies of the prostate stem cell activities, summarize the major progress that has been made during the last two decades regarding the identity of prostate stem/progenitor cells and their niches, and discuss some remaining outstanding questions in the field.

Keywords: Prostate stem cells; lineage hierarchy; lineage tracing; niche; plasticity; prostate regeneration.

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References

    1. Staack A, Donjacour AA, Brody J, Cunha GR, Carroll P. Mouse urogenital development: a practical approach. Differentiation. 2003;71:402–13. - PubMed
    1. Abate-Shen C, Shen NN. Molecular genetics of prostate cancer. Genes Dev. 2000;14:2410–34. - PubMed
    1. Vashchenko N, Abrahamsson PA. Neuroendocrine differentiation in prostate cancer: implications for new treatment modalities. Eur Urol. 2005;47:147–55. - PubMed
    1. Garraway LA, Lin D, Signoretti S, Waltregny D, Dilks J, Bhattacharya N, Loda M. Intermediate basal cells of the prostate: in vitro and in vivo characterization. Prostate. 2003;55:206–18. - PubMed
    1. Tokar EJ, Ancrile BB, Cunha GR, Webber MM. Stem/progenitor and intermediate cell types and the origin of human prostate cancer. Differentiation. 2005;73:463–73. - PubMed

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