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Comment
. 2014 Nov 6;10(11):e1004724.
doi: 10.1371/journal.pgen.1004724. eCollection 2014 Nov.

Let's face it--complex traits are just not that simple

Benedikt Hallgrimsson  1 , Washington Mio  2 , Ralph S Marcucio  3 , Richard Spritz  4
Affiliations
Comment

Let's face it--complex traits are just not that simple

Benedikt Hallgrimsson et al. PLoS Genet. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Two complementary depictions of the developmental architecture underlying the genotype–phenotype map for complex traits.
A captures the idea that large amounts of genetic variation funnel to smaller numbers of pathways and processes. These processes then interact to produce structured and modulated phenotypic variation in a complex trait. B, which derives from Wagner , shows the many-to-many mapping of genes to traits; while both Cs show the modular pattern of gene effects on processes and the effects of processes on sets of phenotypic traits. These depictions illustrate some of the complexity involved in constructing models of genotype–phenotype relations in complex traits.
See this image and copyright information in PMC

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  • Modeling 3D facial shape from DNA.
    Claes P, Liberton DK, Daniels K, Rosana KM, Quillen EE, Pearson LN, McEvoy B, Bauchet M, Zaidi AA, Yao W, Tang H, Barsh GS, Absher DM, Puts DA, Rocha J, Beleza S, Pereira RW, Baynam G, Suetens P, Vandermeulen D, Wagner JK, Boster JS, Shriver MD. Claes P, et al. PLoS Genet. 2014 Mar 20;10(3):e1004224. doi: 10.1371/journal.pgen.1004224. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24651127 Free PMC article.

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