Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Nov 6;10(11):e1004724.
doi: 10.1371/journal.pgen.1004724. eCollection 2014 Nov.

Let's face it--complex traits are just not that simple

Benedikt Hallgrimsson  1 , Washington Mio  2 , Ralph S Marcucio  3 , Richard Spritz  4
Affiliations
Comment

Let's face it--complex traits are just not that simple

Benedikt Hallgrimsson et al. PLoS Genet. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Two complementary depictions of the developmental architecture underlying the genotype–phenotype map for complex traits.
A captures the idea that large amounts of genetic variation funnel to smaller numbers of pathways and processes. These processes then interact to produce structured and modulated phenotypic variation in a complex trait. B, which derives from Wagner , shows the many-to-many mapping of genes to traits; while both Cs show the modular pattern of gene effects on processes and the effects of processes on sets of phenotypic traits. These depictions illustrate some of the complexity involved in constructing models of genotype–phenotype relations in complex traits.
See this image and copyright information in PMC

Comment in

Comment on

  • Modeling 3D facial shape from DNA.
    Claes P, Liberton DK, Daniels K, Rosana KM, Quillen EE, Pearson LN, McEvoy B, Bauchet M, Zaidi AA, Yao W, Tang H, Barsh GS, Absher DM, Puts DA, Rocha J, Beleza S, Pereira RW, Baynam G, Suetens P, Vandermeulen D, Wagner JK, Boster JS, Shriver MD. Claes P, et al. PLoS Genet. 2014 Mar 20;10(3):e1004224. doi: 10.1371/journal.pgen.1004224. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24651127 Free PMC article.

References

    1. Claes P, Liberton DK, Daniels K, Rosana KM, Quillen EE, et al. (2014) Modeling 3D Facial Shape from DNA. PLoS Genet 10: e1004224. - PMC - PubMed
    1. Hu D, Marcucio RS (2009) A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm. Development 136: 107–116. - PMC - PubMed
    1. Liu F, van der Lijn F, Schurmann C, Zhu G, Chakravarty MM, et al. (2012) A genome-wide association study identifies five loci influencing facial morphology in Europeans. PLoS Genet 8: e1002932. - PMC - PubMed
    1. Grimston SK, Goldberg DB, Watkins M, Brodt MD, Silva MJ, et al. (2011) Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis. J Bone Miner Res 26: 2151–2160. - PMC - PubMed
    1. Humphries SE, Drenos F, Ken-Dror G, Talmud PJ (2010) Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds. Circulation 121: 2235–2248. - PubMed

Publication types

LinkOut - more resources