Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Feb;133(2):219-20.
doi: 10.1001/jamaophthalmol.2014.4507.

Quantitative autofluorescence as a clinical tool for expedited differential diagnosis of retinal degeneration

Marcela Marsiglia  1 , Winston Lee  1 , Vinit B Mahajan  2 , Jana Zernant  1 , François C Delori  3 , Stephen H Tsang  1 , Janet R Sparrow  1
Affiliations
Case Reports

Quantitative autofluorescence as a clinical tool for expedited differential diagnosis of retinal degeneration

Marcela Marsiglia et al. JAMA Ophthalmol. 2015 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Figures

Figure 1
Figure 1. Fundus Autofluorescence and Color-Coded Quantitative Fundus Autofluorescence (qAF)
Mean grayscale levels in the circularly arranged segments (red) normalized to the reference (red rectangle) (A–C) provide the qAF values (arbitrary grayscale units), which are color coded (D–F).
Figure 2
Figure 2. Quantitative Fundus Autofluorescence (qAF) Values by Age for Study Patient With RPGR Mutation vs Patients With Stargardt Disease 1 and Healthy Individuals
The qAF values (arbitrary grayscale units) acquired from each eye of our patient with an RPGR mutation and qAF values from patients with Stargardt disease 1 are plotted by age. Solid line indicates mean qAF values from 277 healthy individuals; dashed lines, 95% confidence interval.
See this image and copyright information in PMC

References

    1. Thiadens AA, Phan TM, Zekveld-Vroon RC, et al. Writing Committee for the Cone Disorders Study Group Consortium. Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy. Ophthalmology. 2012;119(4):819–826. - PubMed
    1. Bassuk AG, Sujirakul T, Tsang SH, Mahajan VB. A novel RPGR mutation masquerading as Stargardt disease. Br J Ophthalmol. 2014;98(5):709–711. - PMC - PubMed
    1. Zernant J, Schubert C, Im KM, et al. Analysis of the ABCA4 gene by next-generation sequencing. Invest Ophthalmol Vis Sci. 2011;52(11):8479–8487. - PMC - PubMed
    1. Burke TR, Duncker T, Woods RL, et al. Quantitative fundus autofluorescence in recessive Stargardt disease. Invest Ophthalmol Vis Sci. 2014;55(5):2841–2852. - PMC - PubMed
    1. Acton JH, Greenberg JP, Greenstein VC, et al. Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa. Exp Eye Res. 2013;113:41–48. - PMC - PubMed

Publication types