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. 2015 Jan;43(Database issue):D413-22.
doi: 10.1093/nar/gku1056. Epub 2014 Nov 5.

IMGT®, the international ImMunoGeneTics information system® 25 years on

Marie-Paule Lefranc  1 , Véronique Giudicelli  2 , Patrice Duroux  2 , Joumana Jabado-Michaloud  2 , Géraldine Folch  2 , Safa Aouinti  2 , Emilie Carillon  2 , Hugo Duvergey  2 , Amélie Houles  2 , Typhaine Paysan-Lafosse  2 , Saida Hadi-Saljoqi  2 , Souphatta Sasorith  2 , Gérard Lefranc  2 , Sofia Kossida  3
Affiliations

IMGT®, the international ImMunoGeneTics information system® 25 years on

Marie-Paule Lefranc et al. Nucleic Acids Res. 2015 Jan.

Abstract

IMGT(®), the international ImMunoGeneTics information system(®)(http://www.imgt.org) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT(®) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT(®) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) and proteins of the IgSF and MhSF superfamilies. IMGT(®) is built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and 3D structures. The concepts include the IMGT(®) standardized keywords (identification), IMGT(®) standardized labels (description), IMGT(®) standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT(®) comprises 7 databases, 17 online tools and 15,000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data. Tools and databases are used in basic, veterinary and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA). IMGT(®) is freely available at http://www.imgt.org.

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Figures

Figure 1.
Figure 1.
IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org. Databases are shown as cylinders and tools as rectangles. The web resources are not shown.
Figure 2.
Figure 2.
IMGT/mAb-DB, http://www.imgt.org. The part of the results for two entries is shown with the links to IMGT/2Dstructure-DB and IMGT/3Dstructure-DB, respectively.
See this image and copyright information in PMC

References

    1. Lefranc M.-P., Giudicelli V., Ginestoux C., Jabado-Michaloud J., Folch G., Bellahcene F., Wu Y., Gemrot E., Brochet X., Lane J., et al. IMGT®, the international ImMunoGeneTics information system®. Nucleic Acids Res. 2009;37:D1006–D1012. - PMC - PubMed
    1. Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014;5:1–22. - PMC - PubMed
    1. Lefranc M.-P., Lefranc G. The Immunoglobulin FactsBook. London: Academic Press; 2001.
    1. Lefranc M.-P., Lefranc G. The T cell receptor FactsBook. London: Academic Press; 2001.
    1. Lefranc M.-P. Nomenclature of the human immunoglobulin genes. In: Coligan JE, Bierer BE, Margulies DE, Shevach EM, Strober W, editors. Current Protocols in Immunology, A.1P.1-A.1P.37. Hoboken, NJ: John Wiley and Sons; 2000. pp. 1–37. - PubMed

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