Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;43(Database issue):D1057-63.
doi: 10.1093/nar/gku1113. Epub 2014 Nov 6.

The GOA database: gene Ontology annotation updates for 2015

Rachael P Huntley  1 , Tony Sawford  2 , Prudence Mutowo-Meullenet  2 , Aleksandra Shypitsyna  2 , Carlos Bonilla  2 , Maria J Martin  2 , Claire O'Donovan  2
Affiliations

The GOA database: gene Ontology annotation updates for 2015

Rachael P Huntley et al. Nucleic Acids Res. 2015 Jan.

Abstract

The Gene Ontology Annotation (GOA) resource (http://www.ebi.ac.uk/GOA) provides evidence-based Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB). Manual annotations provided by UniProt curators are supplemented by manual and automatic annotations from model organism databases and specialist annotation groups. GOA currently supplies 368 million GO annotations to almost 54 million proteins in more than 480,000 taxonomic groups. The resource now provides annotations to five times the number of proteins it did 4 years ago. As a member of the GO Consortium, we adhere to the most up-to-date Consortium-agreed annotation guidelines via the use of quality control checks that ensures that the GOA resource supplies high-quality functional information to proteins from a wide range of species. Annotations from GOA are freely available and are accessible through a powerful web browser as well as a variety of annotation file formats.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Annotation quality checks in the Protein2GO curation interface. If an annotation is incomplete or fails sanity checks, a warning is given and the curator is unable to add the annotation to the database. In the annotation pictured, an identifier is missing from the ‘With/From’ field.
Figure 2.
Figure 2.
Faceted filtering of annotation data in QuickGO. Annotations in the GOA database can be filtered for particular subsets. Here the filters for human (taxon:9606) and direct assay evidence used in manual assertion (ECO identifier ECO:0000314) have been applied.
Figure 3.
Figure 3.
Usage restrictions for GO terms. Information about the usage of each term is included on the GO term page in QuickGO. In the case of ‘metaphase’ (GO:0051323), this term cannot be used in primary GO annotations.
See this image and copyright information in PMC

References

    1. Dimmer E.C., Huntley R.P., Alam-Faruque Y., Sawford T., O'Donovan C., Martin M.J., Bely B., Browne P., Mun Chan W., Eberhardt R., et al. The UniProt-GO Annotation database in 2011. Nucleic Acids Res. 2011;40:D565–D570. - PMC - PubMed
    1. Balakrishnan R., Harris M.A., Huntley R., Van Auken K., Cherry J.M. A guide to best practices for Gene Ontology (GO) manual annotation. Database. 2013;2013:doi:10.1093/database/bat054. - PMC - PubMed
    1. Burge S., Kelly E., Lonsdale D., Mutowo-Muellenet P., McAnulla C., Mitchell A., Sangrador-Vegas A., Yong S.Y., Mulder N., Hunter S. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Database. 2012;2012:doi:10.1093/database/bar068. - PMC - PubMed
    1. Morgat A., Coissac E., Coudert E., Axelsen K.B., Keller G., Bairoch A., Bridge A., Bougueleret L., Xenarios I., Viari A. UniPathway: a resource for the exploration and annotation of metabolic pathways. Nucleic Acids Res. 2012;40:D761–D769. - PMC - PubMed
    1. Barrell D., Dimmer E., Huntley R.P., Binns D., O'Donovan C., Apweiler R. The GOA database in 2009—an integrated Gene Ontology Annotation resource. Nucleic Acids Res. 2009;37:D396–D403. - PMC - PubMed

Publication types