Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Nov 7;115(11):904-7.
doi: 10.1161/CIRCRESAHA.114.305284.

Can endothelial progenitor cells treat patients with refractory angina?

Courtney Premer  1 , Joshua M Hare  2
Affiliations
Editorial

Can endothelial progenitor cells treat patients with refractory angina?

Courtney Premer et al. Circ Res. .
No abstract available

Keywords: Editorials; stem cells.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr. Hare reported having a patent for cardiac cell-based therapy, receiving research support from Biocardia, having equity interest and board membership in Vestion Inc,

Figures

Figure 1
Figure 1
Schematic of the PROGENITOR randomized trial and results. 28 patients with refractory angina were treated with either CD133+ cells (n=19) or placebo (n=9). Abbreviations are as follows: MACCE= Major Adverse Cardiac and Cerebrovascular Event, CCS= Canadian Cardiovascular Society, SPECT=single photon emission computed tomography, LVEF= left ventricular ejection fraction, UV= unipolar voltage, LLS= linear local shortening.
Figure 2
Figure 2
Chart illustrating various cell types,,, used in clinical trials for refractory angina. Blue arrows indicate the reported results from cell trials,,,,, with red wording indicating results reported by Jiminez-Quevado et al.
See this image and copyright information in PMC

Comment on

References

    1. Henry TD, Satran D, Jolicoeur EM. Treatment of refractory angina in patients not suitable for revascularization. Nat Rev Cardiol. 2014;11:78–95. - PubMed
    1. Li N, Yang YJ, Zhang Q, Jin C, Wang H, Qian HY. Stem cell therapy is a promising tool for refractory angina: a meta-analysis of randomized controlled trials. The Canadian journal of cardiology. 2013;29:908–14. - PubMed
    1. Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arteriosclerosis, thrombosis, and vascular biology. 2003;23:1185–9. - PubMed
    1. Zampetaki A, Kirton JP, Xu Q. Vascular repair by endothelial progenitor cells. Cardiovascular Research. 2008;78:413–421. - PubMed
    1. Aicher A, Zeiher AM, Dimmeler S. Mobilizing endothelial progenitor cells. Hypertension. 2005;45:321–5. - PubMed