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Case Reports
. 2014 Sep;7(3):141-3.
doi: 10.4103/0974-620X.142598.

Paediatric choroidal neovascular membrane secondary to toxoplasmosis treated successfully with anti-vascular endothelial growth factor

Gaurav Mathur  1 , Amala Elizabeth George  2 , Parveen Sen  3
Affiliations
Case Reports

Paediatric choroidal neovascular membrane secondary to toxoplasmosis treated successfully with anti-vascular endothelial growth factor

Gaurav Mathur et al. Oman J Ophthalmol. 2014 Sep.

Abstract

The purpose of this report was to evaluate the role anti-VEGF in management of CNVM secondary to ocular toxoplasmosis. Young female diagnosed as a case of bilateral ocular toxoplasmosis presented with complaints of diminution of vision in the right eye. Fundus examination showed an active CNVM adjacent to toxoplasmosis scar. In view of active CNVM, patient was administered intravitreal ranibizumab. A total of 2 injections of intravitreal ranibizumab were given. Fundus showed a scarred CNVM adjacent to the toxoplasma scar with no clinical signs of activity. Anti-VEGF therapy has been successfully used to improve visual and anatomical outcome in juxtafoveal (deleted subfoveal)CNVM secondary to toxoplasmosis.

Keywords: Anti-VEGF; pediatric CNVM; toxoplasmosis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) FFA shows active leakage from the CNVM adjacent to toxoplasma scar (b) FFA shows persisting leakage from the CNVM at 2 month follow up (c) FFA shows scarred CNVM adjacent a toxoplasmosis scar with scar staining (d) FFA shows scarred CNVM with no active leakage
Figure 2
Figure 2
(a) OCT image along the vertical axis shows an active CNVM superior to fovea with surrounding sub-retinal hemorrhage. A small pigmentation is seen within the lesion causing shadowing. Sub-retinal fluid is seen at the fovea. Foveal depression is maintained (b) OCT image through the same location as the previous visit shows a partially regressed CNVM with minimal subretinal fluid and retinal thickening at the inferior edge of the lesion (c) Vertical OCT scan shows a well defined hyper reflective scarred CNVM with no evidence of activity (d) OCT scan shows scarring CNVM with complete resolution of SRF. Note the thinning of IS-OS junction at fovea
See this image and copyright information in PMC

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