Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jun 13;4(2):125-153.
doi: 10.3390/bs4020125. eCollection 2014 Jun.

Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders

Mona M Boules  1 , Paul Fredrickson  1 , Amber M Muehlmann  2 , Elliott Richelson  1
Affiliations
Review

Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders

Mona M Boules et al. Behav Sci (Basel). .

Abstract

Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.

Keywords: addiction; animal models; antipsychotic drugs; autism spectrum disorder; neurotensin; schizophrenia.

PubMed Disclaimer

References

    1. Carraway R., Bhatnagar Y.M. Isolation, structure and biologic activity of chicken intestinal neurotensin. Peptides. 1980;1:167–174. doi: 10.1016/0196-9781(80)90082-0. - DOI - PubMed
    1. Hermans E., Maloteaux J.M. Mechanisms of regulation of neurotensin receptors. Pharmacol. Ther. 1998;79:89–104. doi: 10.1016/S0163-7258(98)00009-6. - DOI - PubMed
    1. Mazella J. Sortilin/neurotensin receptor-3: A new tool to investigate neurotensin signaling and cellular trafficking? Cell Signal. 2001;13:1–6. doi: 10.1016/S0898-6568(00)00130-3. - DOI - PubMed
    1. Tanaka K., Masu M., Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron. 1990;4:847–854. doi: 10.1016/0896-6273(90)90137-5. - DOI - PubMed
    1. Chalon P., Vita N., Kaghad M., Guillemot M., Bonnin J., Delpech B., Le Fur G., Ferrara P., Caput D. Molecular cloning of a levocabastine-sensitive neurotensin binding site. FEBS Lett. 1996;386:91–94. doi: 10.1016/0014-5793(96)00397-3. - DOI - PubMed

LinkOut - more resources