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. 2014 Oct;4(4):293-7.
doi: 10.4103/2225-4110.128906.

Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by Paclitaxel in mice

Tsugunobu Andoh  1 , Ryo Kitamura  1 , Hirotoshi Fushimi  2 , Katsuko Komatsu  3 , Naotoshi Shibahara  4 , Yasushi Kuraishi  1
Affiliations

Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by Paclitaxel in mice

Tsugunobu Andoh et al. J Tradit Complement Med. 2014 Oct.

Abstract

Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; Niú Chē Shèn Qì Wán), hachimijiogan (HJG; Bā Wèi Dì Huáng Wán), and rokumigan (RMG; Liù Wèi Wán), would relieve paclitaxel-induced mechanical allodynia in mice. A single intraperitoneal injection of paclitaxel (5 mg/kg) induced mechanical allodynia, which peaked on day 14 after injection. On day 14 after paclitaxel injection, oral administration of GJG (0.1-1.0 g/kg) produced a significant inhibition of established allodynia, but HJG and RMG did not affect the allodynia. Repeated oral administration of GJG (0.1-1.0 g/kg) starting from the day after paclitaxel injection did not affect allodynia development, but significantly inhibited allodynia exacerbation. Repeated oral administration of HJG produced a slight inhibition of allodynia exacerbation, but that of RMG did not. These results suggest that prophylactic administration of GJG is effective in preventing the exacerbation of paclitaxel-induced allodynia. The herbal medicines Plantaginis Semen ( Chē Qián Zǐ) and Achyranthis Radix ( Niú Xī), which are present in GJG but not in HJG, may contribute to the inhibitory action of GJG on the exacerbation of paclitaxel-induced allodynia.

Keywords: Goshajinkigan; Hachimijiogan; Mechanical allodynia; Paclitaxel; Rokumigan.

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Figures

Figure 1
Figure 1
Effects of single administration of goshajinkigan (GJG), hachimijiogan (HJG), and rokumigan (RMG) on the established mechanical allodynia after paclitaxel injection. (a) Development of mechanical allodynia after a single injection of paclitaxel. Mice were injected intraperitoneally with paclitaxel (5 mg/kg) or vehicle on day 0. GJG (b), HJG (c), RMG (d), or vehicle (5% gum arabic) was orally administered on day 14 after paclitaxel injection. Data are presented as mean and standard error of the mean (n = 5-6). *P < 0.05 compared to vehicle (Holm-Sidak multiple comparisons)
Figure 2
Figure 2
Effects of prophylactic administration of goshajinkigan (GJG), hachimijiogan (HJG), and rokumigan (RMG) on paclitaxel-induced mechanical allodynia. Paclitaxel (5 mg/kg) was injected intraperitoneally in mice, and GJG (a), HJG (b), RMG (c), or vehicle (5% gum arabic) was administered orally once daily from the day after the paclitaxel injection. Data are presented as mean and standard error of the mean (n = 5-6). *P < 0.05 compared to vehicle (Holm-Sidak multiple comparisons)
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