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Multicenter Study
. 2015 Mar;13(1):12-9.
doi: 10.3121/cmr.2014.1236. Epub 2014 Nov 7.

Impact of different etiologies of bronchiectasis on the pulmonary function tests

Agnaldo José Lopes  1 , Gustavo Bittencourt Camilo  2 , Sara Lucia Silveira de Menezes  3 , Fernando Silva Guimarães  3
Affiliations
Multicenter Study

Impact of different etiologies of bronchiectasis on the pulmonary function tests

Agnaldo José Lopes et al. Clin Med Res. 2015 Mar.

Abstract

Background: Bronchiectasis develops along the natural course of several respiratory and systemic conditions and induces significant changes in the morphofunctional structure of airways. Our objective was to assess the impact of various causes of bronchiectasis on clinical data, pulmonary function tests, and high-resolution computed tomography (HRCT).

Methods: The present report was a cross-sectional study that was conducted with 112 consecutive patients with bronchiectasis, who were allocated to five groups, as follows: sequelae of tuberculosis, history of non-tuberculosis infection, cystic fibrosis (CF), primary ciliary dyskinesia (PCD), and rheumatoid arthritis. All of the participants underwent spirometry, whole-body plethysmography, measurement of the diffusing capacity for carbon monoxide (DLco), and HRCT.

Results: The highest HRCT score was exhibited in patients with CF (6.03 ± 1.03). The values of forced expiratory volume in 1 second (FEV1) (52.2 ± 17.7%) and DLco (74.1 ± 15.2%) were lower in patients with sequelae of tuberculosis. The increase in the residual volume was more accentuated in the patients with CF (193.5 ± 39.5%) and PCD (189 ± 36.4%). By the multivariate analysis, the cause of FEV1 and bronchiectasis, HRCT score, and degree of dyspnea behaved as independent predictors of DLco.

Conclusion: In individuals with bronchiectasis, the pulmonary function abnormalities are associated with the etiology of the underlying disease.

Keywords: Bronchiectasis; Respiratory function tests; Respiratory mechanics; Tomography.

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Figures

Figure 1
Figure 1
Relationship between the forced expiratory volume in 1 second (FEV1) and the high-resolution computed tomography (HRCT) score (r = −0.77; P <0.0001).
Figure 2
Figure 2
Mean and standard deviation of forced expiratory volume in 1 second (FEV1) according to the modified Medical Research Council (MRC) scale. Significant difference (P < 0.0001) was found between the FEV1 and MRC scales (degree 0/1 > degree 2 = degree 3 > degree 4).
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