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. 2015 Jan 7;27(1):65-72.
doi: 10.1002/adma.201403724. Epub 2014 Nov 10.

Synthesis and characterization of a library of in-situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery

Timothy M O'Shea  1 , Alex A Aimetti, Eunha Kim, Volkan Yesilyurt, Robert Langer
Affiliations

Synthesis and characterization of a library of in-situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery

Timothy M O'Shea et al. Adv Mater. .

Abstract

A transesterfication reaction is used to synthesize tri-thiol-functionalized-ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume-constrained anatomical sites.

Keywords: candida antarctica lipase B; drug delivery; hydrogels; polymeric materials; thiol-michael addition.

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