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Meta-Analysis
. 2014 Nov 10:4:6887.
doi: 10.1038/srep06887.

Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: a systematic review and meta-analysis

Tingkun Shi  1 , Wenjuan Lv  1 , Li Zhang  1 , Jianhuan Chen  1 , Haoyu Chen  1
Affiliations
Meta-Analysis

Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: a systematic review and meta-analysis

Tingkun Shi et al. Sci Rep. .

Abstract

Human leukocyte antigen (HLA)-DR4/HLA-DRB1*04 has been reported to be a risk factor for Vogt-Koyanagi-Harada disease (VKH) with various strength of association. Its sub-alleles were also found to be associated with VKH. However the results were inconsistent. In this study, we systematically searched the related literature, pooled the odds ratios (ORs) and 95% confidence interval (CI) of association of HLA-DR4/HLA-DRB1*04 or its sub-alleles with VKH from individual studies, and explored the potential source of heterogeneity. A total of 1853 VKH patients and 4164 controls from 21 articles were included in this meta-analysis. The pooled OR of association of HLA-DR4/HLA-DRB1*04 and VKH was 8.42 (95% CI: 5.69-12.45). There were significant heterogeneity (I(2) = 71%). Subgroup analysis indicated that ethnicity was the source of heterogeneity (all I(2) = 0, ORs ranged from 2.09-13.69 in subgroups). The sub-alleles, HLA-DRB1*0404 (OR = 2.57), 0405 (OR = 10.31) and 0410 (OR = 6.52) increased the risk of VKH; 0401 (OR = 0.21) protected VKH; while other sub-alleles were not associated with VKH. Our meta-analysis confirmed the association between VKH and HLA-DR4/DRB1*04, found the strength of association is different in different ethnic groups, and identified HLA-DRB1*0404, 0405 and 0410 as risk sub-alleles while 0401 as protective sub-allele.

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Figures

Figure 1
Figure 1. Flow diagram showing the result of literature screening for meta-analysis.
Figure 2
Figure 2. Meta-analysis of the association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada (VKH) disease.
(A): Forest plot showing the odds ratios (ORs) of VKH carrying HLA-DR4/HLA-DRB1*04 in individual studies, sub-groups based on ethnicity and the pooled results. (B): Funnel plots for positive rate of HLA-DR4/HLA-DRB1*04 between VKH cases and controls. (C). Exclusion sensitivity plot showing the results of pooled ORs after omitting each study.
Figure 3
Figure 3. Forest plots of the association of HLA-DRB1*04 sub-alleles with Vogt-Koyanagi-Harada (VKH) disease.
See this image and copyright information in PMC

References

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