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. 2014 Dec;16(12):900-6.
doi: 10.1111/jch.12435. Epub 2014 Nov 10.

Cerebral blood flow and cognitive function in patients with metabolic syndrome: effect of antihypertensive therapy

Irina Efimova  1 , Natalya Efimova, Yuri Lishmanov
Affiliations

Cerebral blood flow and cognitive function in patients with metabolic syndrome: effect of antihypertensive therapy

Irina Efimova et al. J Clin Hypertens (Greenwich). 2014 Dec.

Abstract

The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Cognitive status of patients with metabolic syndrome (MetS). In patients with MetS, the parameters of cognitive function including attention, mentation, and visual memory were lower compared with that in the control group. *P<.05 reliability of differences vs control group. After treatment, patients with MetS demonstrated improvement in attention, mentation, and visual memory. #P<.05 reliability of differences vs before treatment.
See this image and copyright information in PMC

References

    1. Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am. 2004;33:351–376. - PubMed
    1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356–359. - PubMed
    1. Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002;287:2570–2581. - PubMed
    1. Landsberg L, Aronne LJ, Beilin LJ, et al. Obesity‐related hypertension: pathogenesis, cardiovascular risk, and treatment: a position paper of the Obesity Society and the American Society of Hypertension. J Clin Hypertens (Greenwich). 2013;15:14–33. - PMC - PubMed
    1. Goldstein LB, Bushnell CD, Adams RJ, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:517–584. - PubMed

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