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Review
. 2014 Nov 10:12:336.
doi: 10.1186/1477-7819-12-336.

Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review

Musa Ugur Mermerkaya  1 , Senol Bekmez, Fatih Karaaslan, Murat Danisman, Kemal Kosemehmetoglu, Gokhan Gedikoglu, Mehmet Ayvaz, Ahmet Mazhar Tokgozoglu
Affiliations
Review

Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review

Musa Ugur Mermerkaya et al. World J Surg Oncol. .

Abstract

Background: Various treatment strategies for low-grade chondrosarcomas with variable outcomes have been reported in the literature. The aim of this study was to assess the oncological and functional outcomes associated with intralesional curettage followed by adjuvant therapy comprising high-speed burring, thermal cauterization, and bone cementation with polymethylmethacrylate.

Methods: We performed a retrospective review of 21 consecutive patients with intramedullary low-grade chondrosarcoma of long bones treated by intralesional curettage and adjuvant therapy comprising high-speed burring, thermal cauterization, and cementation at our institution from 2007 to 2012.

Results: The average age of the patients was 48.7 (range, 18-71) years. There were 7 male and 14 female patients. The mean follow-up period was 58.4 (range, 26-85) months after surgery. The treated lesions were located in the proximal humerus (n=10), proximal tibia (n=6), and distal femur (n=5). At the average follow-up time point of 58.4 (range, 26-85) months, no patient had developed local recurrence and no distant metastases were observed. The average Musculoskeletal Tumor Society score among all 21 patients was 95% (84-100).

Conclusions: The combination of intralesional curettage, application of high-speed burring, thermal cauterization, and cementation is an effective treatment strategy for low-grade intramedullary chondrosarcoma of long bones. Excellent oncological and functional results can be obtained.

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Figures

Figure 1
Figure 1
Radiographic findings in low grade chondrosarcoma of proximal humerus. (a) A 55-year-old female patient with a diagnosis of low-grade CS in the proximal humerus. (b,c) Coronaland axial magnetic resonance images at diagnosis. (d) Plain radiography 5 years after surgery.
Figure 2
Figure 2
Radiographic findings in low grade chondrosarcoma of distal femur. (a, b) A 52-year-old female patient with a low-grade chondrosarcoma in the right distal femur. (c, d) Radiographs after 48 months from the surgery.
Figure 3
Figure 3
Microscopic findings in low grade chondrosarcoma (H&E). (a) Hypocellular chondroid lobules on low power magnification. (b) Host bone permeation is a hallmark of chondrosarcoma.
See this image and copyright information in PMC

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