Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Oct 31:7:489-501.
doi: 10.2147/JMDH.S49817. eCollection 2014.

Managing cardiovascular disease risk in patients treated with antipsychotics: a multidisciplinary approach

Matisyahu Shulman  1 , Avraham Miller  2 , Jason Misher  3 , Aleksey Tentler  4
Affiliations
Review

Managing cardiovascular disease risk in patients treated with antipsychotics: a multidisciplinary approach

Matisyahu Shulman et al. J Multidiscip Healthc. .

Abstract

Background: The use of antipsychotic medication in the United States and throughout the world has greatly increased over the last fifteen years. These drugs have significant side effect burdens, many of them relating to cardiovascular health.

Objective: To review the available evidence on the major cardiovascular issues that arise in patients taking antipsychotic medication.

Method: A PubMed literature review was performed to identify recent meta-analyses, review articles, and large studies. Further articles were identified through cited papers and based on expert consultation when necessary.

Results: CLINICAL GUIDANCE ON THE FOLLOWING ADVERSE EFFECTS AND ANTIPSYCHOTICS WAS REVIEWED: electrocardiogram (ECG) changes, (specifically, prolonged QT and risk of torsades de pointes), weight gain, dyslipidemia, metabolic syndrome, and myocarditis. Specific attention was paid to monitoring guidelines and treatment options in the event of adverse events, including dose change, medication switch, or adjuvant therapy.

Keywords: increased mortality; myocarditis; prolonged QT; schizophrenia; weight gain.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Metabolic and weight gain treatment and monitoring algorithm. Abbreviations: BMI, body mass index; HbA1c, glycosylated hemoglobin.
See this image and copyright information in PMC

References

    1. ahrq.gov [homepage on the Internet] Medical Expenditure Panel Survey Publication Details. US Deaprtment of Health and Human Services; 2014. [Accessed August 6, 2014]. Available from: http://meps.ahrq.gov/mepsweb/data_stats/Pub_ProdResults_Details.jsp?pt=S....
    1. Ronsley R, Scott D, Warburton WP, et al. A population-based study of antipsychotic prescription trends in children and adolescents in British Columbia, from 1996 to 2011. Can J Psychiatry. 2013;58(6):361–639. - PubMed
    1. Matone M, Localio R, Huang YS, dosReis S, Feudtner C, Rubin D. The Relationship between Mental Health Diagnosis and Treatment with Second-Generation Antipsychotics over Time: A National Study of US Medicaid-Enrolled Children. Health Serv Res. 2012;47(5):1836–1860. - PMC - PubMed
    1. Laursen TM, Munk-Olsen T, Vestergaard M. Life Expectancy and Cardiovascular Mortality in Persons with Schizophrenia. Curr Opin Psychiatry. 2012;25(2):83–88. - PubMed
    1. Wildgust HJ, Beary M. Are there Modifiable Risk Factors Which will Reduce the Excess Mortality in Schizophrenia? J Psychopharmacol. 2010;24(Suppl 4):37–50. - PMC - PubMed

LinkOut - more resources