Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Sep 30:5:2041731414552701.
doi: 10.1177/2041731414552701. eCollection 2014.

Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment

Michał Lach  1 , Tomasz Trzeciak  2 , Magdalena Richter  2 , Jarosław Pawlicz  2 , Wiktoria M Suchorska  1
Affiliations
Review

Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment

Michał Lach et al. J Tissue Eng. .

Abstract

In recent years, increases in the number of articular cartilage injuries caused by environmental factors or pathological conditions have led to a notable rise in the incidence of premature osteoarthritis. Osteoarthritis, considered a disease of civilization, is the leading cause of disability. At present, standard methods for treating damaged articular cartilage, including autologous chondrocyte implantation or microfracture, are short-term solutions with important side effects. Emerging treatments include the use of induced pluripotent stem cells, a technique that could provide a new tool for treatment of joint damage. However, research in this area is still early, and no optimal protocol for transforming induced pluripotent stem cells into chondrocytes has yet been established. Developments in our understanding of cartilage developmental biology, together with the use of modern technologies in the field of tissue engineering, provide an opportunity to create a complete functional model of articular cartilage.

Keywords: Cartilage; osteoarthritis; regenerative medicine; stem cells.

PubMed Disclaimer

Conflict of interest statement

Declaration of conflicting interests: The authors declare that there is no conflict of interest.

References

    1. Aigner T, Stöve J. Collagens – major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair. Adv Drug Deliv Rev 2003; 55(12): 1569–1593. - PubMed
    1. Madry H, Luyten FP, Facchini A. Biological aspects of early osteoarthritis. Knee Surg Sports Traumatol Arthrosc 2012; 20(3): 407–422. - PubMed
    1. Gomoll AH, Minas T. The quality of healing: articular cartilage. Wound Repair Regen 2014; 22(Suppl. 1): 30–38. - PubMed
    1. Buchanan WW, Kean WF. Osteoarthritis II: pathology and pathogenesis. Inflammopharmacology 2002; 10(1–2): 23–52.
    1. Woo SL-Y, Buckwalter JA. Injury and repair of the musculoskeletal soft tissues. Savannah, Georgia, June 18–20, 1987. J Orthop Res 1988; 6(6): 907–931. - PubMed