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Comparative Study
. 2015 Jan;102(1):57-66.
doi: 10.1002/bjs.9658. Epub 2014 Nov 10.

Use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy

S Huddart  1 , C J Peden, M Swart, B McCormick, M Dickinson, M A Mohammed, N Quiney; ELPQuiC Collaborator Group; ELPQuiC Collaborator Group
Collaborators, Affiliations
Free PMC article
Comparative Study

Use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy

S Huddart et al. Br J Surg. 2015 Jan.
Free PMC article

Abstract

Background: Emergency laparotomies in the U.K., U.S.A. and Denmark are known to have a high risk of death, with accompanying evidence of suboptimal care. The emergency laparotomy pathway quality improvement care (ELPQuiC) bundle is an evidence-based care bundle for patients undergoing emergency laparotomy, consisting of: initial assessment with early warning scores, early antibiotics, interval between decision and operation less than 6 h, goal-directed fluid therapy and postoperative intensive care.

Methods: The ELPQuiC bundle was implemented in four hospitals, using locally identified strategies to assess the impact on risk-adjusted mortality. Comparison of case mix-adjusted 30-day mortality rates before and after care-bundle implementation was made using risk-adjusted cumulative sum (CUSUM) plots and a logistic regression model.

Results: Risk-adjusted CUSUM plots showed an increase in the numbers of lives saved per 100 patients treated in all hospitals, from 6.47 in the baseline interval (299 patients included) to 12.44 after implementation (427 patients included) (P < 0.001). The overall case mix-adjusted risk of death decreased from 15.6 to 9.6 per cent (risk ratio 0.614, 95 per cent c.i. 0.451 to 0.836; P = 0.002). There was an increase in the uptake of the ELPQuiC processes but no significant difference in the patient case-mix profile as determined by the mean Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity risk (0.197 and 0.223 before and after implementation respectively; P = 0.395).

Conclusion: Use of the ELPQuiC bundle was associated with a significant reduction in the risk of death following emergency laparotomy.

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Figures

Figure 1
Figure 1
Cumulative sum analysis before and after implementation of the emergency laparotomy pathway quality improvement care (ELPQuiC) bundle: a site 1, b site 2, c site 3 and d site 4
Figure 2
Figure 2
Risk of 30-day mortality before and after implementation of the emergency laparotomy pathway quality improvement care (ELPQuiC) bundle. Error bars represent 95 per cent c.i.
Figure 3
Figure 3
Compliance with processes of care before and after implementation of the emergency laparotomy pathway quality improvement care (ELPQuiC) bundle: a site 1, b site 2, c site 3 and d site 4. Error bars represent 95 per cent c.i. *More than 15 per cent of data not available. EWS, early warning score; GDFT, goal-directed fluid therapy; ICU, intensive care unit
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