Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;59(1):727-9.
doi: 10.1128/AAC.04078-14. Epub 2014 Nov 10.

Arthritis and benznidazole: more closely related than we thought

E Aldasoro  1 , M J Pinazo  2 , I Oliveira  2 , J Munoz  2 , E Posada  2 , A Requena-Méndez  2 , N Serret  2 , J Gascon  1
Affiliations

Arthritis and benznidazole: more closely related than we thought

E Aldasoro et al. Antimicrob Agents Chemother. 2015 Jan.

Abstract

Chagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug reactions. Although arthralgia is common, arthritis has been reported as a very rare side effect. The objective of this study was to describe arthritis in a cohort of Trypanosoma cruzi-infected patients treated with benznidazole.

PubMed Disclaimer

References

    1. Gascon J, Bern C, Pinazo M-J. 2010. Chagas disease in Spain, the United States and other non-endemic countries. Acta Trop 115:22–27. doi: 10.1016/j.actatropica.2009.07.019. - DOI - PubMed
    1. Viotti R, Vigliano C, Lococo B, Bertocchi G, Petti M, Alvarez MG, Postan M, Armenti A. 2006. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med 144:724–734. doi: 10.7326/0003-4819-144-10-200605160-00006. - DOI - PubMed
    1. Bern C, Montgomery SP, Herwaldt BL, Rassi A Jr, Marin-Neto JA, Dantas RO, Maguire JH, Acquatella H, Morillo C, Kirchhoff LV, Gilman RH, Reyes PA, Salvatella R, Moore AC. 2007. Evaluation and treatment of Chagas disease in the United States: a systematic review. JAMA 298:2171–2181. doi: 10.1001/jama.298.18.2171. - DOI - PubMed
    1. Viotti R, de Noya BA, Araujo-Jorge T, Grijalva MJ, Guhl F, López MC, Ramsey JM, Ribeiro I, Schijman AG, Sosa-Estani S, Torrico F, Gascon J. 2014. Towards a paradigm shift in the treatment of chronic Chagas disease. Antimicrob Agents Chemother 58:635–639. doi: 10.1128/AAC.01662-13. - DOI - PMC - PubMed
    1. Pinazo M-J, Guerrero L, Posada E, Rodríguez E, Soy D, Gascon J. 2013. Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic Chagas disease. Antimicrob Agents Chemother 57:390–395. doi: 10.1128/AAC.01401-12. - DOI - PMC - PubMed

Publication types

LinkOut - more resources