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Case Reports
. 2014 May 12;6(1):5039.
doi: 10.4081/dr.2014.5039. eCollection 2014 Feb 17.

Orofacial Granulomatosis in Children can be the Initial Manifestation of Systemic Disease: A Presentation of Two Cases

Anne Birgitte Simonsen  1 , Mette Deleuran  1
Affiliations
Case Reports

Orofacial Granulomatosis in Children can be the Initial Manifestation of Systemic Disease: A Presentation of Two Cases

Anne Birgitte Simonsen et al. Dermatol Reports. .

Abstract

Orofacial granulomatosis is a chronic granulomatous condition characterized by relapsing and remitting lip swelling and oral involvement that may include deep ulcers, tags and cobblestone formation. It occurs as an independent entity but also in conjunction with systemic diseases such as tuberculosis, sarcoidosis and Crohn's disease. The clinical presentation is not indicative of concomitant systemic disease. To highlight the importance of thorough examination to rule out systemic disease, we present two childhood cases of orofacial granulomatosis, one of which was associated to Crohn's disease.

Keywords: Chron's disease; children; orofacial granulomatosis.

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Conflict of interest statement

Conflict of interests: the authors declare no potential conflict of interests.

Figures

Figure 1.
Figure 1.
Perioral edema, severe fissuring of the lips, angular cheilitis, gingival edema, and cobblestone formation of the mucosa.
Figure 2.
Figure 2.
Chronic swelling of the upper lip. Redness, swelling and hypertrophy of the gingivae.
See this image and copyright information in PMC

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