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. 2014 Dec 3;136(48):16720-3.
doi: 10.1021/ja5094309. Epub 2014 Nov 19.

Ligand-controlled, tunable silver-catalyzed C-H amination

Juliet M Alderson  1 , Alicia M Phelps, Ryan J Scamp, Nicholas S Dolan, Jennifer M Schomaker
Affiliations

Ligand-controlled, tunable silver-catalyzed C-H amination

Juliet M Alderson et al. J Am Chem Soc. .

Abstract

The development of readily tunable and regioselective C-H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C-H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C-H amination.

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Figures

Scheme 1
Scheme 1. Tunable Ag-Catalyzed Nitrene Transfers
Scheme 2
Scheme 2. Mechanistic Studies of Nitrene Transfer
See this image and copyright information in PMC

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