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. 2015 Jul;143(9):1972-81.
doi: 10.1017/S0950268814002970. Epub 2014 Nov 12.

Characteristics and TB treatment outcomes in TB patients with viral hepatitis, New York City, 2000-2010

G Bushnell  1 , N L Stennis  1 , A M Drobnik  1 , D C Proops  1 , S D Ahuja  1 , K Bornschlegel  1 , J Fuld  1
Affiliations

Characteristics and TB treatment outcomes in TB patients with viral hepatitis, New York City, 2000-2010

G Bushnell et al. Epidemiol Infect. 2015 Jul.

Abstract

Literature surrounding the burden of and factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in persons with tuberculosis (TB) disease remains limited and focused on populations outside the USA. Cross-matched New York City (NYC) TB and viral hepatitis surveillance data were used to estimate the proportion of NYC adults diagnosed with TB from 2000 to 2010 with a report of viral hepatitis infection and to describe the impact of viral hepatitis infection on TB treatment completion and death. For 9512 TB patients, HCV infection was reported in 4.2% and HBV infection in 3.7%; <1% of TB patients had both HCV and HBV infection. The proportion of TB patients with HCV infection to die before TB treatment completion was larger than in TB patients without a viral hepatitis report (21% vs. 9%); this association remained when stratified by HIV status. There was no significant difference in death before treatment completion for TB patients with HBV infection compared to TB patients without a viral hepatitis report when stratified by HIV status. These findings reinforce the importance of hepatitis testing and providing additional support to TB patients with viral hepatitis infection.

Keywords: Hepatitis C; hepatitis B; infectious disease epidemiology; surveillance; tuberculosis (TB).

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Conflict of interest statement

None.

Figures

Fig. 1.
Fig. 1.
Study population. aMultidrug-resistant tuberculosis is defined as resistance to at least isoniazid and rifampin. bTwenty-five persons had both HCV and HBV infection and are included in both groups.
See this image and copyright information in PMC

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