Randomised controlled trials for Ebola: practical and ethical issues

Affiliations

¹ National Health Research Ethics Committee, Abuja, Nigeria.
² Hôpital National Ignace Deen, Conakry, Guinea.
³ University of Health and Allied Sciences, Ho, Ghana.
⁴ Hong Kong University-Pasteur Research Pole, School of Public Health, University of Hong Kong, Hong Kong, China.
⁵ New York University Langone Medical Center, New York, NY, USA.
⁶ Institut de Microbiologie et Maladies Infectieuses and INSERM, Paris, France.
⁷ Centre on Global Health Security, Chatham House, London, UK.
⁸ University of Oxford, Oxford, UK.
⁹ Medical Research Council, Uganda Virus Research Institute, Entebbe, Uganda.
¹⁰ Institut National de Recherche Biomedicale, Kinshasa, DR Congo.
¹¹ WHO, Geneva, Switzerland; University of Oxford, Oxford, UK. Electronic address: piero.olliaro@ndm.ox.ac.uk.
¹² London School of Hygiene & Tropical Medicine, London, UK.
¹³ Open Society Initiative for West Africa, Dakar, Senegal.
¹⁴ Nigerian Academy of Science, Lagos, Nigeria.
¹⁵ Institut Pasteur Dakar, Dakar, Senegal.
¹⁶ Open Society Foundations, New York, NY, USA.
¹⁷ Lancaster University, Lancaster, UK.

Clement Adebamowo et al. Lancet. 2014.

. 2014 Oct 18;384(9952):1423-4.

doi: 10.1016/S0140-6736(14)61734-7. Epub 2014 Oct 13.

¹ National Health Research Ethics Committee, Abuja, Nigeria.
² Hôpital National Ignace Deen, Conakry, Guinea.
³ University of Health and Allied Sciences, Ho, Ghana.
⁴ Hong Kong University-Pasteur Research Pole, School of Public Health, University of Hong Kong, Hong Kong, China.
⁵ New York University Langone Medical Center, New York, NY, USA.
⁶ Institut de Microbiologie et Maladies Infectieuses and INSERM, Paris, France.
⁷ Centre on Global Health Security, Chatham House, London, UK.
⁸ University of Oxford, Oxford, UK.
⁹ Medical Research Council, Uganda Virus Research Institute, Entebbe, Uganda.
¹⁰ Institut National de Recherche Biomedicale, Kinshasa, DR Congo.
¹¹ WHO, Geneva, Switzerland; University of Oxford, Oxford, UK. Electronic address: piero.olliaro@ndm.ox.ac.uk.
¹² London School of Hygiene & Tropical Medicine, London, UK.
¹³ Open Society Initiative for West Africa, Dakar, Senegal.
¹⁴ Nigerian Academy of Science, Lagos, Nigeria.
¹⁵ Institut Pasteur Dakar, Dakar, Senegal.
¹⁶ Open Society Foundations, New York, NY, USA.
¹⁷ Lancaster University, Lancaster, UK.

No abstract available

Conflict of interest statement

We declare no competing interests.

Randomisation is essential in Ebola drug trials.
Shaw D. Shaw D. Lancet. 2014 Nov 8;384(9955):1667. doi: 10.1016/S0140-6736(14)61735-9. Epub 2014 Oct 27. Lancet. 2014. PMID: 25441188 No abstract available.

1. Wellcome Trust. [accessed Oct 9, 2014];Ebola treatment trials to be fast-tracked in West Africa. 2014 Sep 23; http://www.wellcome.ac.uk/News/Media-office/Press-releases/2014/WTP05741....
1. Joffe S. Evaluating novel therapies during the Ebola epidemic. JAMA. 2014;312:1299–300. - PubMed