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Case Reports
. 2014 Dec 18;371(25):2402-9.
doi: 10.1056/NEJMoa1409838. Epub 2014 Nov 12.

Clinical care of two patients with Ebola virus disease in the United States

G Marshall Lyon  1 , Aneesh K Mehta, Jay B Varkey, Kent Brantly, Lance Plyler, Anita K McElroy, Colleen S Kraft, Jonathan S Towner, Christina Spiropoulou, Ute Ströher, Timothy M Uyeki, Bruce S Ribner; Emory Serious Communicable Diseases Unit
Collaborators, Affiliations
Free article
Case Reports

Clinical care of two patients with Ebola virus disease in the United States

G Marshall Lyon et al. N Engl J Med. .
Free article

Abstract

West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.

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Comment in

  • Out of Africa--caring for patients with Ebola.
    Rubin EJ, Baden LR. Rubin EJ, et al. N Engl J Med. 2014 Dec 18;371(25):2430-2. doi: 10.1056/NEJMe1412744. Epub 2014 Nov 12. N Engl J Med. 2014. PMID: 25390461 No abstract available.
  • Treatment of Ebola.
    Mehta AK, Lyon GM, Varkey JB. Mehta AK, et al. N Engl J Med. 2015 Apr 23;372(17):1674. doi: 10.1056/NEJMc1500452. N Engl J Med. 2015. PMID: 25901439 No abstract available.
  • Treatment of Ebola.
    Deen J, Dondorp AM, White NJ. Deen J, et al. N Engl J Med. 2015 Apr 23;372(17):1673-4. doi: 10.1056/NEJMc1500452. N Engl J Med. 2015. PMID: 25901440 No abstract available.

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