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Review
. 2015 Jan;22(1):1-5.
doi: 10.1128/CVI.00531-14. Epub 2014 Nov 12.

Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination

Jiangping Ren  1 , Linong Yao  1 , Jimin Sun  1 , Zhenyu Gong  2
Affiliations
Review

Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination

Jiangping Ren et al. Clin Vaccine Immunol. 2015 Jan.

Abstract

The Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination, was developed by I. Vodopija and colleagues of the Zagreb Institute of Public Health in Croatia in the 1980s. It was recommended by WHO as one of the intramuscular (IM) schedules for rabies vaccination in 2010. We reviewed the literature on the immunogenicity, safety, economic burden, and compliance of the Zagreb 2-1-1 regimen. Compared to Essen, another IM schedule recommended by WHO, Zagreb has higher compliance, lower medical cost, and better immunogenicity at an early stage.

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