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Randomized Controlled Trial
. 2015 Jun;22(6):706-11.
doi: 10.1177/1933719114557897. Epub 2014 Nov 12.

Effectiveness and Safety of Lower Doses of Mifepristone Combined With Misoprostol for the Termination of Ultra-Early Pregnancy: A Dose-Ranging Randomized Controlled Trial

Cui-Lan Li  1 , Dun-Jin Chen  2 , Li-Ping Song  2 , Yan Wang  2 , Zhong-Fang Zhang  2 , Ming-Xing Liu  2 , Wei-Ling Chen  2
Affiliations
Randomized Controlled Trial

Effectiveness and Safety of Lower Doses of Mifepristone Combined With Misoprostol for the Termination of Ultra-Early Pregnancy: A Dose-Ranging Randomized Controlled Trial

Cui-Lan Li et al. Reprod Sci. 2015 Jun.

Abstract

This study aimed to investigate the effectiveness and safety of lower doses of mifepristone combined with misoprostol for the termination of ultra-early pregnancy. A total of 2500 women with ultra-early pregnancy (amenorrhea ≤ 35 days) were randomly divided into 5 groups with gradually decreased dose of oral mifepristone from 150 to 50 mg followed by 200 µg of oral misoprostol 24 hours later. The primary end point was complete abortion without surgical intervention. Secondary end points were vaginal bleeding, return of menses, and side effects. Rates of complete abortion were high in all groups. Moreover, the lower doses of mifepristone led to shorter vaginal bleeding period, the return of menses on the expected date, and fewer side effects. Lower doses of mifepristone combined with 200 µg of misoprostol are as effective and safe as higher doses of this combination for the termination of ultra-early pregnancy with lower possibility of vaginal bleeding and side effects.

Keywords: early pregnancy; mifepristone; misoprostol; return of menstruation; termination.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The study procedure. mf indicates mifepristone; ms, misoprostol; G, group.
See this image and copyright information in PMC

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