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Case Reports
. 2014 Nov 4:10:609-13.
doi: 10.2147/VHRM.S66283. eCollection 2014.

Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis

Brooke M Lamparello  1 , Cameron R Erickson  2 , Arun Kulthia  3 , Vasudev Virparia  3 , Zeyar Thet  3
Affiliations
Case Reports

Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis

Brooke M Lamparello et al. Vasc Health Risk Manag. .

Abstract

A previously healthy 21-year-old man presented with back pain, bilateral extremity pain, and right lower extremity weakness, paresthesias, and swelling. Sonographic examination revealed diffuse deep vein thrombosis (DVT) in the femoral and popliteal venous system. CT imaging revealed hypoplasia of the hepatic inferior vena cava (IVC) segment with formation of multiple varices and collateral veins around the kidneys. Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT. The rare, often overlooked occurrence of attenuated IVC, especially in the setting of hypercoagulable state, can predispose patients to significant thrombosis.

Keywords: deep vein thrombosis (DVT); inferior vena cava (IVC); lower extremities; thrombophilic; venography.

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Figures

Figure 1
Figure 1
Chest CT with contrast. Azygos-hemiazygos (red arrows) and the hepatic portion of the IVC (yellow arrow). Abbreviations: CT, computed tomography; IVC, inferior vena cava.
Figure 2
Figure 2
Hepatic IVC (circled). Abbreviation: IVC, inferior vena cava.
Figure 3
Figure 3
CT scan with contrast. Note: Extensive network of collaterals (circled). Abbreviation: CT, computed tomography.
Figure 4
Figure 4
Lower extremity venogram. Interrupted IVC (yellow arrow) and lower extremity drained by hemiazygos veins (red arrow). Abbreviation: IVC, inferior vena cava.
See this image and copyright information in PMC

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