Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct;11(4):481-6.
doi: 10.4306/pi.2014.11.4.481. Epub 2014 Oct 20.

Abelson helper integration site-1 gene variants on major depressive disorder and bipolar disorder

Stefano Porcelli  1 , Chi-Un Pae  2 , Changsu Han  3 , Soo-Jung Lee  4 , Ashwin A Patkar  5 , Prakash S Masand  6 , Beatrice Balzarro  1 , Siegfried Alberti  1 , Diana De Ronchi  1 , Alessandro Serretti  1
Affiliations

Abelson helper integration site-1 gene variants on major depressive disorder and bipolar disorder

Stefano Porcelli et al. Psychiatry Investig. 2014 Oct.

Abstract

Objective: The present study aimed to explore whether 4 single nucleotide polymorphisms (SNPs) within the AHI1 gene could be associated with major depressive disorder (MD) and bipolar disorder (BD), and whether they could predict clinical outcomes in mood disorders.

Methods: One hundred and eighty-four (184) patients with MD, 170 patients with BD and 170 healthy controls were genotyped for 4 AHI1 SNPs (rs11154801, rs7750586, rs9647635 and rs9321501). Baseline and final clinical measures for MD patients were assessed through the Hamilton Rating Scale for Depression (HAM-D). Allelic and genotypic frequencies in MD and BD subjects were compared with those of each disorder and healthy group using the χ(2) statistics. Repeated measures ANOVA was used to test possible influences of SNPs on treatment efficacy.

Results: The rs9647635 A/A was more represented in subjects with BD as compared with MD and healthy subjects together. The rs9647635 A/A was also more presented in patients with MD than in healthy subjects. With regard to the allelic analysis, rs9647635 A allele was more represented in subjects with BD compared with healthy subjects, while it was not observed between patients with MD and healthy subjects.

Conclusion: Our findings provide potential evidence of an association between some variants of AHI1 and mood disorders susceptibility but not with clinical outcomes. However, we will need to do more adequately-powered and advanced association studies to draw any conclusion due to clear limitations.

Keywords: AHI1; Association study; Bipolar disorder; Depression; Mood disorder; Susceptibility.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Linkage disequilibrium (LD) plot.
See this image and copyright information in PMC

References

    1. Alda M. Genetic factors and treatment of mood disorders. Bipolar Disord. 2001;3:318–324. - PubMed
    1. Pae CU, Chiesa A, Porcelli S, Han C, Patkar AA, Lee SJ, et al. Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia. Neuropsychobiology. 2012;65:1–11. - PubMed
    1. Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry. 2006;163:109–114. - PubMed
    1. Smoller JW, Finn CT. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet. 2003;123C:48–58. - PubMed
    1. Zubenko GS, Maher BS, Hughes HB, 3rd, Zubenko WN, Scott Stiffler J, Marazita ML. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet. 2004;129B:47–54. - PubMed

LinkOut - more resources