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Case Reports
. 2014 Oct;5(4):488-90.
doi: 10.4103/2229-5178.142515.

Clear cell sarcoma

Pinar Ozuguz  1 , Mukadder Kocak  2 , Pinar Atasoy  3 , Ibrahim Vargel  4 , Tarik Cavusoglu  4
Affiliations
Case Reports

Clear cell sarcoma

Pinar Ozuguz et al. Indian Dermatol Online J. 2014 Oct.

Abstract

Malignant melanoma (MM) of soft tissue, also called clear cell sarcoma (CCS) of tendons and aponeuroses, derives from the neural crest. CCS is similar morphologically to MM but has no precursor skin lesion, and instead, has a characteristic chromosomal translocation. Prognosis is related to the tumor size. Early recognition and initial radical surgery is the key to a favorable outcome. The tumor has to be differentiated from other benign and malignant lesions of the soft tissues, such as fibrosarcoma. The demonstration of melanin and a positive immunohistochemical reaction for S-100 protein and HMB-45 can assist in the differential diagnosis. We report the case of a 58-year-old woman with CCS arising from the soft tissue of her little finger.

Keywords: Clear cell sarcoma; HMB-45; S-100 protein; finger; hand; poor prognosis.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Fifth finger revealing an ulcerated lesion measuring approximately 6 × 8 cm
Figure 2
Figure 2
Tumor composed of solid nests of spindle cells delineated by fibrous septa (H and E, ×100)
Figure 3
Figure 3
Tumor cells showing diffuse and intense positivity for both anti-S-100 and anti-HMB-45 antibodies (×100)
Figure 4
Figure 4
Right hand with fifth finger amputated
See this image and copyright information in PMC

References

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