Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct;5(4):510-6.
doi: 10.4103/2229-5178.142528.

Pentoxifylline and its applications in dermatology

Iffat Hassan  1 , Konchok Dorjay  1 , Parvaiz Anwar  1
Affiliations

Pentoxifylline and its applications in dermatology

Iffat Hassan et al. Indian Dermatol Online J. 2014 Oct.

Abstract

Pentoxifylline is a methyl-xanthine derivative with many anti inflammatory effects. Pentoxifylline has been found to be effective for many dermatological as well as non-dermatological conditions. It has been used both as primary drug as well as adjuvant and is a safe and relatively cost-effective alternative drug. In this article, we review the literature and highlight various important aspects of pentoxifylline.

Keywords: Cost effective; methyl xanthine; pentoxifylline; safe.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Molecular structure of pentoxifylline
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Smith RV, Waller ES, Doluisio JT, Bauza MT, Puri SK, Ho I, et al. Pharmacokinetics of orally administered pentoxifylline in humans. J Pharm Sci. 1986;75:47–52. - PubMed
    1. Ward A, Clissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987;34:50–97. - PubMed
    1. Samlaska CP, Winfield EA. Pentoxifylline. J Am Acad Dermatol. 1994;30:603–21. - PubMed
    1. van Furth AM, Verhard-Seijmonsbergen EM, van Furth R, Langermans JA. Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha, IL-1 beta IL-10 by human leucocytes. Immunology. 1997;91:193–6. - PMC - PubMed
    1. Strieter RM, Remick DG, Ward PA, Spengler RN, Lynch JP, 3rd, Larrick J, et al. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun. 1988;155:1230–6. - PubMed